H5N1: Vaccine candidate against chikungunya fever proves successful

might be in time to stop a North American epidemic…

Excerpt:

A prophylactic vaccine candidate against Chikungunya fever, developed by the Austrian biotech company Themis Bioscience GmbH induces a significant neutralizing immune response and was also confirmed as safe. These are the major interim results of a phase 1 clinical study of the company’s Chikungunya vaccine candidate that uses a standard anti-measles vaccine as a vector.

The Chikungunya epidemic, currently raging through the Caribbean, illustrates the urgent necessity to develop an effective vaccine against the rapid spread of the disease in tropical regions, now also threatening the North American continent.

The Vienna-based biotech company Themis Bioscience GmbH today received the interim results of a phase 1 clinical study of its Chikungunya fever prophylactic vaccine. The study was carried out on 42 subjects in the Department of Clinical Pharmacology at the Vienna General Hospital, and confirms the expectations pinned on the vaccine: it not only proved to be well tolerated and safe, but also exhibited the required immune response in the form of neutralizing antibodies. Even the lowest doses used showed to be effective, and increasing doses led to respective stronger immune responses in the study subjects.

Commenting on the positive results, Themis founder and CEO, Dr. Erich Tauber, stated: “The confirmed tolerance, safety and immune response show the suitability of our Themaxyn platform. This uses a standard anti-measles vaccine as a vector and constitutes the basis of our pipeline, comprising a Dengue fever vaccine candidate and vaccine constructs for other rapidly spreading infectious diseases. The anti-measles vaccine has already proven itself a million times over, and hence the Themaxyn platform offers an excellent safety profile and clear advantages in terms of a validated, low-cost production process.”

The Chikungunya epidemic, currently rampant in the Caribbean, shows that such a platform could soon be needed on a larger geographic scale. Having started in the Dominican Republic, it has already reached Haiti and fears are now growing that the disease could spread further to the USA, where isolated cases of Chikungunya have been observed in recent years.

To date, no effective vaccine for this serious disease has been available and the US Centers for Disease Control and Prevention (CDC) are said to have warned hospitals throughout the country. Accordingly, representatives of the CDC are quoted in The Wall Street Journal as saying: “We are preparing for the potential introduction into the United States”.

June 12, 2014

http://crofsblogs.typepad.com/h5n1/2014/06/vaccine-candidate-against-chikungunya-fever-proves-successful.html

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