Artificial Sweeteners Induce Glucose Intolerance By Altering The Gut Microbiota

Nature (2014) doi:10.1038/nature13793

Received 27 March 2014 Accepted 28 August 2014

Published online 17 September 2014

Abstract

Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike.

NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota.

These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS.

We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects.

Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.

Ebola Infection control is not working ProMED-Mail Post

Ebola Infection control is not working
A ProMED-mail post
Date: 14 Sep 2014
From: Bjorg Marit Andersen

Infection control concerning EVD is not working, especially when more than 240 [now 300] healthcare personnel have been infected, and more than 120 workers have died. Guidelines used to control SARS in 2003 should be used, not “contact and droplet protection of 1-2 meters,” as is still recommended by WHO.

Personal protective equipment (PPE) for contact and airborne infections should be used because of
a) respiratory symptoms,
b) a big distance — up to 9 meters — for droplets when coughing and sneezing (Bourouiba et al. J Fluid Mechanics 2014;745:537-563.),
c) re-aerolization from the environment, bed clothes etc.,
d) long survival of the virus outside the body, and
e) high lethality.

Healthcare workers (HCW) and helpers should be protected with PPE as they were during the SARS epidemic. The SARS epidemic was an infection control success by the healthcare system of some countries in Asia in 2003. But WHO should not repeat the same failure as was done during the early phase of the SARS-epidemic by using “contact and droplet isolation.” Separate hospitals for EVD should be built, like in China (1000 beds in 8 days for SARS), and only patients with laboratory documented EVD should be cohorted. Suspected cases should be isolated separately.

HCW and helpers should be trained and especially observed concerning [putting] PPE on and taking [it] off. The observers should also use PPE. During the SARS epidemic, HCW were re-contaminated by not knowing how to take off PPE.

Exposed people and patients with other diseases should be treated in professional triages to reduce the population’s fear of being EVD-infected during contact with healthcare. Exposed people should be taken care of by professional helpers.

There is a need for a lot of resources, especially concerning infection control work.


Bjorg Marit Andersen, MD, PhD
Professor in Hygiene and Infection Control
Speciality: Medical Microbiology
Former chief, Department of Hospital Infections
Oslo University Hospital – Ulleval
Gaustadveien 1a 0372 Oslo, Norway

A ProMED-mail post

ProMED-mail is a program of the
International Society for Infectious Diseases

Drought Map for September 9 2014

Ebola epidemic = 100s of 1000s of cases n last years

stolen from slashdot…
Despite recent advances in medicine to treat Ebola, epidemiologists are not hopeful that the outbreak in west Africa will be contained any time soon. Revised models for the disease’s spread expect the outbreak to last 12 to 18 months longer, likely infecting hundreds of thousands of people. “While previous outbreaks have been largely confined to rural areas, the current epidemic, the largest ever, has reached densely populated, impoverished cities including Monrovia, the capital of Liberia gravely complicating efforts to control the spread of the disease. … What worries public health officials most is that the epidemic has begun to grow exponentially in Liberia. In the most recent week reported, Liberia had nearly 400 new cases, almost double the number reported the week before. Another grave concern, the W.H.O. said, is ‘evidence of substantial underreporting of cases and deaths.’ The organization reported on Friday that the number of Ebola cases as of Sept. 7 was 4,366, including 2,218 deaths.” Scientists are urging greater public health efforts to slow the exponential trajectory of the disease and bring it back under control.”
http://science.slashdot.org/story/14/09/13/1727208/us-scientists-predict-long-battle-against-ebola

at least half are likely to die… total cases into the hundreds of thousands over the next year… but the math models can’t predict what’ll happen when continent wide panic / hysteria grips 100s of millions of people… but, hey, look, over there – a just ginned up dandy little war to entertain y’all… n remember! Keep Shopping!!

here’s where they stole it from:

http://www.nytimes.com/2014/09/13/world/africa/us-scientists-see-long-fight-against-ebola.html?_r=0

READING BY WRITERS – TUESDAY SEPTEMBER 16, 2014

CAROL CONNOLLY Saint Paul Poet Laureate curates

Free and Open to the Public

Historic University Club Saint Paul 420 Summit Ave

Bar is open and serves throughout the evening.

5:00 dinner, not connected to the performance. You are welcome

Reservations at 651-222-1751. No need to be a member

7:00 Prelude music by violinist Mary Scallen and flutist Jim Miller.

TUESDAY SEPTEMBER 16, 2014

7:30 p.m. Featured Readers are: :

KYLE ADAMSON, poet and MFA student at Bennington College, earned a BFA from Hamline University, winner of the 2010 AWP Intro to Journals Award in poetry, and Pushcart nominee. His poems have appeared in the ARTFUL DODGE; REVOLVER; ALASKA QUARTERLY REVIEW; WATER-STONE REVIEW; MIDWAY JOURNAL, SPECTER, and r.kv.r.y. Kyle served in the Marine Corps infantry, and was twice deployed to Iraq.

KATHRYN KYSAR, poet, author of two books of poetry, DARK LAKE and PRETEND THE WORLD, edited the anthology RIDING SHOTGUN; WOMEN WRITE ABOUT THEIR MOTHERS. Kathryn has been the recipient of numerous prestigious fellowships and residencies. Her poems have been heard on A WRITER’S ALAMANAC, and appeared in anthologies including TOSING ALONG THE WAYand GOOD POEMS AMERICAN PLACES.. Kathryn co-chairs the creative writing program at Anoka-Ramsey Community College and teaches creative writing classes at Hamline University and the Loft Literary Center. Her latest project was a collaborative CD of poetry from PRETEND THE WORLD.

DAVID MURA, poet, whose newest collection of poetry is THE LAST INCANATIONS.

His three other books of poetry are ANGELS FOR THE BURNING; THE COLORS OF DESIRE, winner of the Carl Sandburg Award, and AFTER WE LOST OUR WAY, winner of The National Poetry Contest. Mura has written two memoirs, WHERE THE BODY MEETS MEMORY and TURNING JAPANESE, winner of the Josephine Miles PEN Award and a NYTimes Notable Book. His novel is FAMOUS SUICIDES OF THE JAPANESE EMPIRE. His blog and website: www.davidmura.com

No remuneration for any of us, as you know, but we do pass the so-called hat

for Public Art Saint Paul and Sidewalk Poetry.

DONNA CARNES, poet who speaks and teaches about resilience, is widely published in a variety of venues. Her work has been influenced by her experience with ambiguous loss. Her forthcoming books of poetry include GOLDEN GATE; HORIZON; POSTCARDS IN BETWEEN. A forthcoming book of fiction is HELM. Donna lives n Middleton, Wisconsin

MICHAEL SAUNTRY, poet, attended UMD, U of M Law School, and served in the Army. He

practiced law with the Collins, Buckley, Sauntry, and Haugh law firm until four years ago when cancer retired him. He began writing poems 40 plus years ago, has a stash of 2000, some of which, he hopes are good. “Cancer took away two years of my life” he says, but gave me more than it took. It helped me realize that what I was chasing was really chasing me.

2.

CARRIE WASLEY, poet, has written 1,000 fine poems in 1,000 days. She allocates her time between working for the Juvenile Justice Advisory Committee (JJAC) as the MN Juvenile Justice Specialist – each state has only one – to contributing to five separate boards – everything from an arts board to a political PAC. Somehow this still allows Carrie time to write poetry.

JOHN MINCZESKI, poet with five full-length collections, two chapbooks and several anthologies he’s edited, continues to publish poems around the country and locally, including LINDEN ST. REVIEW; SAINT PAUL ALMANCE; SCREECH OWL; BARN OWL REVIEW; the now defunct but beautiful literary website CERISE PRESS, and more. He’s been honored with a Bush Artist Fellowship, National Endowment for the Arts Fellowship, and was an Edelstein-Killer Distinguished Fellow in the U of M creative writing department. John served, for several years, on the review committee for the Sidewalk Poetry Project

NAOMI COHN, poet and creator of KNOWN BY HEART, a collaborative project on poetry, memory and performance. Her book BETWEEN NECTAR & ETERNITY, Red Dragonfly, Press 2013, presents 14 of Cohn’s poems about insects and other social creatures, given wings by original artwork by Red Dragonfly’s award-winning founder and editor, Scott King, who knows a thing or two about bugs. Cohn notes “insects have been a strange muse for me. To paraphrase Groucho Marx “- outside of a bug, a book is a poet’s best friend, inside of a bug, it’s too dark to read…”

Readings last just about an hour. Books will be sold Readers will sign.

Ma Bear gets a little help

Drought Map for September 2 2014

Ebola on the verge

we saw this coming months ago, as soon as Ebola hit major urban areas… if this had been human2human h5n1 or h7n9 deaths would be in the 10s of millions by now and increasing at exponential rates… next time it will be… how many hospital beds in your town? how many respirators? gonna turn your sports stadiums and shopping malls into hospitals?
http://www.wired.com/2014/09/cdc-director-ebola/

Médecins Sans Frontières… Ebola – the world is losing the battle

Médecins Sans Frontières: “Six months into the worst Ebola epidemic in history, the world is losing the battle”

Via MSF UK, another well-deserved kick in our collective ass: West Africa: Bio-disaster response urgently needed in Ebola fight. Excerpt:

World leaders are failing to address the worst ever Ebola epidemic, and states with biological-disaster response capacity, including civilian and military medical capability, must immediately dispatch assets and personnel to West Africa, the international medical humanitarian organisation Médecins Sans Frontières/Doctors Without Borders (MSF) announced today in a special briefing at the United Nations organised by the office of the UN Secretary General and the World Health Organisation (WHO).

The further spread of the virus will not be prevented without a massive deployment of such specialised medical units to bolster epidemic control efforts in affected countries, said MSF.

In a speech delivered to UN member states, MSF International President Dr Joanne Liu denounced the lack of deployment of resources, which has to-date relied on overstretched ministries of health and private non-governmental organisations, to tackle the exceptionally large outbreak.

International response lethally inadequate

Despite repeated calls by MSF for a massive mobilisation on the ground, the international response has been lethally inadequate.

MSF medical teams have been battling the outbreak in West Africa since March. Non-governmental groups and the United Nations cannot alone implement the WHO Global Roadmap to fight the ever growing and unpredictable outbreak. Transmission rates have reached levels never before reported in past Ebola outbreaks.

Six months into the worst Ebola epidemic in history, the world is losing the battle to contain it, said Dr Liu.

Leaders are failing to come to grips with this transnational threat. The WHO announcement on 8th August that epidemic constituted a public health emergency of international concern has not led to decisive action, and states have essentially joined a global coalition of inaction, she said.

Deploy civilian or military medical teams now

Many countries possess biological threat response mechanisms. They can deploy trained civilian or military medical teams in a matter of days, in an organised fashion, and with a chain of command to assure high standards of safety and efficiency to support the affected countries.

MSF insists, however, that any military assets and personnel deployed to the region should not be used for quarantine, containment, or crowd control measures. Forced quarantines have only bred fear and unrest, rather than stem the virus.

MSF Ebola teams overwhelmed

Funding announcements and the deployment of a few experts do not suffice, said Dr Liu.

States with the required capacity have a political and humanitarian responsibility to come forward and offer a desperately needed, concrete response to the disaster unfolding in front of the worlds eyes, said Dr Liu.

Rather than limit their response to the potential arrival of an infected patient in their countries, they should take the unique opportunity to actually save lives where immediately needed, in West Africa.