3 Minutes To Midnight… Bulletin of the Atomic Scientists

2015

IT IS 3 MINUTES TO MIDNIGHT

Unchecked climate change, global nuclear weapons modernizations, and outsized nuclear weapons arsenals pose extraordinary and undeniable threats to the continued existence of humanity, and world leaders have failed to act with the speed or on the scale required to protect citizens from potential catastrophe. These failures of political leadership endanger every person on Earth.” Despite some modestly positive developments in the climate change arena, current efforts are entirely insufficient to prevent a catastrophic warming of Earth. Meanwhile, the United States and Russia have embarked on massive programs to modernize their nuclear triads—thereby undermining existing nuclear weapons treaties. “The clock ticks now at just three minutes to midnight because international leaders are failing to perform their most important duty—ensuring and preserving the health and vitality of human civilization.”

New Benefit – treating brain, breast, n prostate CA – to Lou Gehrig’s Drug

“Because the GRM1 protein is also found in breast and prostate cancers, pre-treatment with riluzole before radiation for these particular cancers might also result in the same outcomes,”

http://www.dddmag.com/news/2015/01/scientists-find-new-benefit-lou-gehrigs-drug?et_cid=4374968&et_rid=633376228&location=top

A drug used to treat Lou Gehrig’s disease (ALS) makes radiation more effective when treating melanoma that has metastasized to the brain, according to new research on laboratory models at Rutgers Cancer Institute of New Jersey and the Ernest Mario School of Pharmacy at Rutgers.

Melanoma – the deadliest of skin cancers – is often resistant to radiation therapy, creating a risk of neurotoxicity when large doses need to be administered to the whole brain in order to treat the disease. The new study, published in the current print edition of Pigment Cell & Melanoma Research (doi: 10.1111pcmr.12327), examines radiation treatment when combined with the drug riluzole and its impact on melanoma that has spread to the brain.

Riluzole targets a protein known as GRM1 that is often abnormally produced by melanoma cells and increases growth and spread of the disease. Riluzole has been approved by the United States Food and Drug Administration and is being used to to block activation of the GRM1 protein in the treatment of ALS, a disease that affects nerve cells in the brain and spinal cord.

In the new Rutgers research, investigators found that treating the melanoma daily, over a 37 day period, with riluzole and a weekly dose of radiation, led to a decrease in tumor cell growth.

“What this indicates is that riluzole sensitizes GRM1, helping these proteins act like a beacon for radiation so that only melanoma cells with the GRM1 protein will be targeted, sparing the rest of the brain and preserving the brain’s functionality,” notes senior author, Suzie Chen, Cancer Institute member and professor of chemical biology at the Ernest Mario School of Pharmacy.

“With approximately 50 percent of patients with melanoma developing brain metastasis and fewer than 13 percent of those patients surviving one year or more, identifying new therapies for this population is paramount,” said James S. Goydos, director of the Melanoma and Soft Tissue Oncology Program at the Cancer Institute and professor of surgery at Rutgers Robert Wood Johnson Medical School, who is another author on the study. He also notes their findings could have even broader implications. “Because the GRM1 protein is also found in breast and prostate cancers, pre-treatment with riluzole before radiation for these particular cancers might also result in the same outcomes,” he said.

Source: Rutgers University

trains belong on railroads…

black ice on the Jersey turnpike a couple of days ago…
put the f-in’ trains back on the tracks n get ’em off the highways…

https://www.youtube.com/watch?v=O7ApxVyskuI#t=35

Drug Co. CEO Blames Drug Industry For Increased Drug Resistance

“We cannot accept that rivers in India show higher concentrations of active antibiotic than the blood of someone undergoing treatment.”

“…Karl Rotthier, chief executive of the Dutch DSM Sinochem Pharmaceuticals, claims lax procedures at drugs companies are the real cause. “Most antibiotics are now produced in China and India and I do not think it is unjust to say that the environmental conditions have been quite different in these regions. Poor controls mean that antibiotics are leaking out and getting into drinking water. They are in the fish and cattle that we eat, and global travel and exports mean bacteria are traveling. That is making a greater contribution to the growth of antibiotic resistance than over-prescribing”, Rothier said. “We cannot have companies discharging untreated waste water into our environment, contributing to illness and, worse, antibacterial resistance. We cannot accept that rivers in India show higher concentrations of active antibiotic than the blood of someone undergoing treatment.”

http://science.slashdot.org/story/15/01/19/1734200/drug-company-ceo-blames-drug-industry-for-increased-drug-resistance

Woodchopper…

I’ve always liked this cuz it reminds me of Great Great Uncle Evar’s place over near Martell Wisconsin…
the painting is ‘Woodchopper’ by Thomas Hart Benton 1936

READING BY WRITERS Tuesday Jan. 20 730pm Univ Club St Paul

Saint Paul Almanac presents Saint Paul Poet Laureate CAROL CONNOLLY

hosting READING BY WRITERSat the historic University Club Saint Paul, 420 Summit Avenue. www.universityclubofstpaul.com5:00 dinner; reservations necessary.

Bar is open before, during, and after the 7:30 reading.

Reading is open to the public.

Funds raised at the event support Saint Paul Almanac, which celebrates and documents the city’s history and diversity; its creative forces; its residents’ memories and current experiences; and the ever-changing urban landscape.

Carol Connolly has hosted this event for over fifteen years. The series has supported writers and readers by showcasing emerging and established artists.

The first reading of 2015 highlights artists performing for the first time at a Reading by Writers event.

On Tuesday, January 20, 2015, 7:30 p.m., our featured readers are:

Erica Christ / Writer/Playwright/Storyteller
In addition to managing the Black Forest Inn in Minneapolis, Erica has used this unique venue to house her Cheap Theater series, which has drawn large crowds and rave reviews for years. Many people recognize her as one of the state’s premier storytellers, however, she has also written a German Christmas cookie cookbook and has probably planned more asparagus festivals than anyone in America.

Paula Cisewski / Poet/Teacher/Collaborator

Paula is the author of Ghost Fargo (selected by Franz Wright for the Nightboat Prize), Upon Arrival (Black Ocean), and three chapbooks of poetry. Co-host of the Maeve’s Sessions Reading Series and co-concoctor of JoyFace Poetry & Art happenings, Paula has received fellowships from the Minnesota State Arts Board and the Jerome Foundation, and she was the 2014 Banfill-Locke writer-in-residence.

Karlyn Coleman / Writer/Poet

Karlyn was recently awarded a Minnesota Emerging Writers’ Grant. Her stories have been published in Paper Darts, McSweeney’s, Canvas, and Revolver. Her story “Ice Roads” was awarded first place in fiction at Crab Orchard Review. She lives in South Minneapolis with her husband, two boys, and a dog named Happy.

Sierra DeMulder / Poet

Sierra is a two-time National Poetry Slam champion, a 2014 McKnight Fellowship recipient, and the author of two collections of poetry: The Bones Below and New Shoes on a Dead Horse (2010, 2012, Write Bloody Publishing). Sierra is the curriculum director of the Gustavus Adolphus College Institute of Spoken Word and Poetry Slam, an annual summer writing camp

Jon Finley / Musician
While Jon studied guitar at the University of Wisconsin-Milwaukee he developed a unique picking technique that has gained him notoriety and awards in international competitions. In addition to creating music Jon is an animal rights activist. During a recent trip to Sri Lanka he put together a video series to raise funds to help care for Sri Lanka’s stray dog population. Jon will be backed up by Mike Finley, known across Saint Paul as the capital city’s rebel poet. For decades Mike has created multimedia presentations of literature. During the 2014 winter holidays he performed with the New Standards at the State Theater and promoted his new book Victory through Song.

Paul Mattes / Poet
Paul is originally from Cleveland and has been published in Taylor and O’Neill’s Open Interpretation series. Although he reads at numerous venues across the metro, he has made Christopher Title’s Barbaric Yawp series his home. When Paul isn’t writing verse he enjoys memorizing Pi digits (he’s currently up to fifty) and spending time with his two children.

Cindy Tran / Poet
Cindy is the 2015 recipient of the Loft Spoken Word Immersion Fellowship. She is originally from California and studied English Literature at UCLA. Cindy spent several years designing laboratories at top business schools. She has done civil engineering research at St. Anthony Falls Laboratory and worked on debris flow research at the California Institute of Technology.

Artists will sell books and CDs at the event. Cash and checks are accepted and money for merchandise sold goes directly to the artists.

Frank responds to heckler…