Rays Dancing

just for the sheer helluvit… woohoo, dig those front n back flips… too bad lower animals have no sense of joy de vivre

Asteroid Visits Los Angeles

Grand Opening – Bear Center Unveils Northwoods Ecology Hall

Newsletter-Logo3
Friday, 10 July 2015
Bear Center Unveils Northwoods Ecology Hall
Grand Opening: July 18, 2pm

20150128 CougarEly, MN – It’s a dream come true for nature lovers, especially bear biologist Lynn Rogers. On Saturday, July 18th, the North American Bear Center opens doors to its new Northwoods Ecology Hall, a $1.5 million expansion which nearly doubles the size of the education, exhibit and research facility.

The public is invited to the grand opening with a 2 pm ribbon cutting ceremony.

Built as a global learning center, the new 8,000 square foot addition showcases the habitat and history of the Northwoods. Moose, caribou, white-tail deer, and timber wolf mounts are on display, as well as a 10-foot aquarium and terrariums featuring amphibians. Interactive touch screens describe how the species interact with each other, including black bears. Nature sounds lend ambiance from state-of-the-art audio.

20150205 GrayFox“Awesome, is the word we hear most,” said Rogers, of those who have toured the new facility. “We hear excitement in their voices and see their wide-eyed enthusiasm. It’s no wonder because we’ve had experts in Ely from across the country to make this ecology center a world class place.”

The ecology hall also houses the Hope Learning Center, a classroom with broadcast technology. The center is named for Hope, the cub Lily gave birth to in January 2010, when an Internet sensation occurred when people around the world watched the birth on a live web cam.

Since 1994, Rogers has wanted to build an ecology museum celebrating the Boundary Waters area. Combined with the bear center, a dream of honoring the Northwoods’ wildlife and landscape is now reality.

20150218 GreatHornedOwl“The worldwide attention we’re seeing is fantastic,” Ely Mayor Chuck Novak said. “People are excited about the bear center expansion. It’s a big boost to our economy having visitors here from all over the world.”

The grand opening of the ecology hall coincides with the annual Lilypad Picnic Weekend which takes place in Ely, July 17-19th. Hundreds of visitors pack Ely’s hotels, motels and restaurants.

20150219 OtterThe mission of the non-profit North American Bear Center is to advance the long-term survival of bears worldwide by replacing misconceptions with scientific facts about bears, their role in ecosystems, and their relations with humans. Founded by Dr. Lynn Rogers, the NABC opened in May 2007.

The NABC is located at 1926 State Highway 169, a mile west of Ely. For admission fees, please call or visit our website at www.bear.org. Grilled hot dogs and refreshments will be served at the grand opening.

For more information:
North American Bear Center: 877-365-7879 or 218-365-7879
WRI/NABC Media Relations Director Bev Hauptli: MediaRelations
North American Bear Center: www.bear.org
Wildlife Research Institute: www.bearstudy.org

Drought Map for July 7th 2015

Eagle Bluff’s Newest Addition!

Eagle Bluff’s Newest Addition!If you’ve been to downtown Lanesboro lately you may have notice a new addition!

Summer at Eagle Bluff
Hello Ray,

If you’ve been to downtown Lanesboro lately you may have notice…
outpost

Eagle Bluff opened up shop on Parkway Ave – right next to Pedal Pushers! We have named this new venture the “Eagle Bluff Oupost” and our goal is to be Your Outdoor Connection!

Of course you can stop in to learn more and sign up for Eagle Bluff programs, like Summer High Ropes, Becoming an Outdoor Family, and the Skills School! You can also learn about programs that Eagle Bluff is partnering on, like the July 25th FREE Root River Field Day with the Friends of the Root River. Finally, we can connect you to other outdoor adventures in the Lanesboro and SEMN region like where to rent bikes, explore caves, and find great fishing spots.

Please stop by and visit us at the Outpost! We plan to be open Mondays, Tuesdays, Fridays and Saturdays through the end of August. Our hours may change during the fall season. Hope to see you there!

Steph_2011_Fall_Event
Cheers,
Stephanie Davidson,
Public Programs Coordinator

High ropes at Eagle Bluff
“Summer High Ropes”
Tuesdays & Saturdays
June, July, August
Register Here!
Becoming an Outdoor Family at Eagle Bluff
“Becoming an Outdoor Family”
August 8-9
Recommended for ages 6 and up
Register Here!
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Eagle Bluff Environmental Learning Center 28097 Goodview Dr Lanesboro, MN 55949

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WPR Chapter A Day CITY OF THIEVES read by Karl Schmidt

WISCONSIN PUBLIC RADIO – CHAPTER A DAY

Karl Schmidt reads from “City of Thieves” by David Benioff. An extraordinary story about friendship in the harsh world of Leningrad during the German siege of WWII.
http://www.wpr.org/programs/chapter-day

Goodhue Co Historical Soc. History Break: “Jesse James in Minnesota” and Bluffs & Brews

July Programs:

July 15th–History Break: “Jesse James in Minnesota”
featuring Hayes Scriven. 12-1 PM Free of charge.
July 18th–Bluffs & Brews: Paddle the Vermillion River
$5 ticket price. 3:30-6:30 PM Contact the Historical Society for info.

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July 15th & 18th Programs

July 15th, 12-1 PM–History Break: “Jesse James in Minnesota”
featuring Northfield Historical Society Director Hayes Scriven

Many Minnesotans know of the Jesse James showdown in Northfield, but few have heard the story from the perspective of the Northfield community. Historical Society Director Hayes Scriven presents original historical research on this much-discussed topic, focusing on the brave Minnesotans from Northfield that stood up to Jesse James and his outlaw gang.

The “History Break” lunchtime program series takes place on the third Wednesday of every month, and features a variety of historical topics. Instead of a regular lunch break, take a history break and learn more about your county, state, and nation.
July 18th, 3:30 PM-6:30 PM–Bluffs & Brews: Paddle the Vermillion River

This month’s Bluffs & Brews program takes participants on a canoe paddling trip down the Vermillion River. Guides will describe the river’s history, explain the modern significance the river has to Goodhue County, and point out flora and fauna along the way. After the trip, the group will celebrate a successful adventure and head to the Staghead Gastropub, where guests enjoy a classic dining experience with a modern flavor.

Tickets are $5 and include canoe and equipment rental and entry to win door prizes courtesy of Vasque Footwear. Food and beverages are not included in the ticket price. Pre-registration is required, and space is very limited. Tickets can be purchased by contacting the Goodhue County Historical Society.

Goodhue County Historical Society

Hours of Operation:
Tues-Sat: 9 AM–5 PM
Sunday: 1 PM–5 PM

651-388-6024
www.goodhuecountyhistory.org
info

Copyright © 2015 Goodhue County Historical Society, All rights reserved.
You are receiving this email because you support Goodhue County Historical Society. Thank you! Sending emails rather than letters reduces our costs and keeps you informed.

Our mailing address is:
Goodhue County Historical Society 1166 Oak St
Red Wing, MN 55066

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Loon with Pearled Water Drops

Loon by Brian Plath in Minnesota Photography Club
July 6 ·

Rapamycin Dosing New Paradigm For Treating ‘Inflammaging’ And Cancer

July 6th, 2015 in Medical research /

Credit: Martha Sexton/public domain

Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies. The finding, published in Nature Cell Biology, shows that once disrupted, it takes time for the inflammatory loop to reestablish, providing proof-of-principal that intermittent dosing could provide a way to reap the benefits of rapamycin, an FDA-approved drug that extends lifespan and healthspan in mice, while lessening safety issues associated with its use.

“We think this could provide a paradigm shift in the treatment of age-related disease, including cancer,” said Buck professor Judith Campisi, PhD, senior scientist on the study. “Imagine the possibility of taking a pill for a few days or weeks every few years, as opposed to taking something with side effects every day for the rest of your life. It’s a new way of looking at how we could deal with age-related maladies.”

Campisi’s team, led by postdoctoral fellow Remi-Martin Laberge, PhD, collaborated with teams led by Peter Nelson, MD, at the Fred Hutchinson Cancer Research Center and Pankaj Kapahi, PhD, at the Buck Institute. They showed that rapamycin reduced the secretion of inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR pathway, which promotes growth. The team gave rapamycin to mice with prostate cancer—after they had been treated with DNA-damaging chemotherapy. Describing the inflammatory loop associated with senescence, Campisi said the results could impact current treatment of cancer patients. “DNA-damaging chemotherapy causes senescence, both to the tumor and its microenvironment. The tumor shrinks but the immediate tissue environment is inflamed. We think signals from those inflamed cells trigger residual cancer cells to grow again. In the mice, rapamycin suppressed the ability of the tumor cells to relapse.” Most importantly, Campisi said the results may help explain why rapamycin has had mixed results as a treatment for cancer. “It’s being given to patients as a way of stopping the growth of tumors. But we think that rapamycin may also be beneficial for those tumors that are driven by inflammation,” she said. “It needs to be tested in a population most likely to benefit.”

Nelson, a member of the Human Biology and the Public Health Sciences Divisions at Seattle’s Fred Hutchinson Cancer Research Center, hopes to do just that. A practicing oncologist who specializes in treating prostate cancer, Nelson is planning a clinical trial utilizing rapamycin together with standard treatments. “Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,” he said. “We are eager to test this in select patients.”

“These findings may indeed have applicability for both aging and tumor growth,” said Harvey Cohen, MD, Director, Center for the Study of Aging & Human Development at Duke University’s School of Medicine. “Senescence-activated inflammation could be driving the increased incidence of cancer that we see with aging.” Dr. Cohen, whose research program includes studies on cancer in the elderly and molecular pathways that lead to functional decline, said. “While this study took place in mice, the work sets the scene to do early clinical trials in humans. Inflammation has a role in almost all tumor development and some cancers are more inflammatory than others. It would be interesting to see the effect that rapamycin has on those tumors and the surrounding tissue.”

Laberge said the paradigm-shifting potential of intermittent dosing is based on the fact that it takes time for the inflammatory loop (fueled by the senescence-associated secretory phenotype or SASP) to form and time for it to re-establish itself after a brief treatment of rapamycin. “Rapamycin blocks the production of a protein called IL-1alpha. This in turn, suppresses IL6, a well-known inflammatory cytokine, at the level of transcription, which prevents the production of the IL6 protein,” said Laberge. “Because it acts at a deeper level within the cellular process it takes longer for it to get started again.” He also points out that treatment with rapamycin selectivity impacts the SASP, preserving the function of factors essential for wound healing. “It’s an elegant solution – imagine using a small hammer to delicately knock out one thing that is causing problems. We knocked it out and it stayed out long enough to benefit the health of the animal.”

The study is expected to generate interest in the age research field among scientists studying rapamycin and its analogs as they look for ways to forestall late-life diseases. Rapamycin is an immune modifier first used after kidney transplant. While there is a lot of excitement about the drug, which improved seniors’ response to the flu vaccine in a clinical trial last year, there are concerns about its side effects, especially with long-term use. Rapamycin can make patients susceptible to some opportunistic infections and has been linked to hyperglycemia, which can cause type 2 diabetes, and high levels of triglycerides in the blood, which can contribute to heart disease. “We have yet to fully understand why suppressing the mTOR pathway via rapamycin increases lifespan and healthspan in mice. This work helps illuminates the puzzle,” said Campisi. “Perhaps the mice are living longer because they have less overall inflammation, and maybe intermittent dosing will make it possible for us to use it more widely in humans.”

More information: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation, Nature Cell Biology, DOI: 10.1038/ncb3195

Provided by Buck Institute for Age Research

“New paradigm for treating ‘inflammaging’ and cancer.” July 6th, 2015. http://medicalxpress.com/news/2015-07-paradigm-inflammaging-cancer.html

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