The Beautiful Cure

Davis notes that in a healthy person, cortisol fluctuates predictably throughout the day and that, as a result, the performance of some drugs varies substantially depending on when they are administered. This phenomenon can be exploited for increased vaccine response. Davis estimates, for example, that “giving the [flu] vaccine in the morning would be able to protect over half of elderly people.” One wonders then why drugs, by and large, are not prescribed for dosing at specific times of day, despite the fact that “fifty-six of the top hundred bestselling drugs in the USA… target the product of genes that change their activity with the time of day.”
http://blogs.sciencemag.org/books/2018/09/04/the-beautiful-cure/

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