Engineering bacteria to intelligently sense and respond to disease states, from infections to cancer, has become a promising focus of synthetic biology. Rapid advances in genetic engineering tools have enabled researchers to “program” cells to perform various sophisticated tasks. For example, a network of genes can be wired together to form a genetic circuit in which cells can be engineered to sense the environment and modulate their behavior or produce molecules in response.
Recent research has found that many bacteria selectively colonize tumors in vivo, prompting scientists to engineer them as programmable vehicles, biological “robots” in other words, to deliver anticancer therapeutics. Researchers are also developing new, “smart” medicines by programming bacteria to tackle other diseases, such as gastrointestinal disease and infections. Key to advancing such “living medicines” is being able to identify the best therapeutic candidates.
https://phys.org/news/2019-04-platform-recreates-cancer-dish-quickly.html
Filed under: #!!# |
Hans Howe 