Blocking of lymphotoxin beta receptor signaling in mice lung tissue disrupted the formation of the immune cell follicles, prevented lung epithelial cell death and, surprisingly, at the same time triggered lung tissue regeneration. “The lung in those mice regenerated despite the continuous exposure to chronic cigarette smoke. We observed a full restoration of lung tissue,” says Dr. Thomas M. Conlon, part of Yildirim’s group at Helmholtz Zentrum München. “Moreover, as the mice lungs healed, co-morbidities such as muscle wasting also improved.”


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